Improved DBM ROC Methods in Diagnostic Radiology
This grant addressed a fundamental methodological problem in diagnostic radiology research: how to evaluate the diagnostic performance of imaging modalities. Receiver operating characteristic (ROC) analysis is an accepted procedure for measuring how well imaging modalities allow physicians to detect disease. Traditional statistical comparison of different imaging modalities only analyzes ROC measures of a single radiologist from each modality. Dorfman, Berbaum and Metz (1992) developed a statistical methodology that overcomes this limitation and provides a comprehensive framework within which to analyze ROC studies with multiple readers, taking into account both reader-sample and case-sample variation. Over time, the Obuchowski-Rockette (1995) methodology of estimating variances and covariances was incorporated was added as an option for the statistical analyses. The Obuchowski-Rockette (OR) and Dorfman-Berbaum-Metz (DBM) methodologies allow greater statistical power to detect clinically meaningful differences in diagnostic performance than single-radiologist approaches. Its validity has been tested extensively using computer simulations and has wide acceptance in diagnostic radiology experiments. Because OR-DBM methodology relies on ROC analysis for its dependent measures, the robustness and accuracy of the ROC analysis affect the statistical precision and power of OR-DBM methodology. The software now includes options for “proper” ROC analysis modules that provide more interpretable ROC results than traditional "improper" ROC analysis. The software is now referred to as the "OR-DBM MRMC" software rather than the "DBM MRMC" software.
OR-DBM MRMC References
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